I take Levothyroxine, pravastatin, and losartin. Considering drug interactions, what is the best time during the day for me to take these medications?
Although there are no listed interactions between Levothyroxine, Pravastatin and Losartan there is a recommended time of the day when each of your medication should be taken.
Levothroxine should be taken ideally in the morning half an hour before breakfast. This will ensure that the full dose will be absorbed into the body. Food, particularly foods that contain calcium and iron can interfere with absorption of Levothyroxine so reduce the amount the body receives. If you have eaten then it is best to wait about two hours before taking Levothyroxine tablets.
Pravastatin is best taken at bedtime because most of the cholesterol is synthesized by the liver mainly at night. The enzyme HMG CoA reductase controls the synthesis of cholesterol in the liver. Pravastatin inhibits this enzyme so reduces cholesterol. Evidence shows that taking statins at night is more effective.
Losartan is normally taken at night when the treatment is first started to minimise the risk of postural hypotension. Postural hypotension means dizziness when changing your posture. This can lead to a fall. Once the treatment is established and your body has had time to adjust Losartan can be taken in the morning. It is important to take it at the same time of the day morning or at night whatever time best suits you.
These recommendations are just ideal times. However, if these times are inconvenient for you then you should take your medications when you can. It is important to take them once a day every day so gain the maximum benefit.
Answered by the Health at Hand nurses